Human WAVE 1 (WASF1) activation kit by CRISPRa

CAT#: GA105956

WASF1 CRISPRa kit - CRISPR gene activation of human WASP family member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: WASF1
• Locus ID: 8936
• Kit Components:

  GA105956G1, WASF1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105956G2, WASF1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105956G3, WASF1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001024934, NM_001024935, NM_001024936, NM_003931
• Synonyms: SCAR1; WAVE; WAVE1
• Summary: The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]