Human CHRNA6 activation kit by CRISPRa

CAT#: GA105969

CHRNA6 CRISPRa kit - CRISPR gene activation of human cholinergic receptor nicotinic alpha 6 subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CHRNA6
• Locus ID: 8973
• Kit Components:

  GA105969G1, CHRNA6 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105969G2, CHRNA6 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105969G3, CHRNA6 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001199279, NM_004198
• Synonyms: CHNRA6
• Summary: This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010]