Human Huntingtin Associated Protein 1 (HAP1) activation kit by CRISPRa

CAT#: GA105986

HAP1 CRISPRa kit - CRISPR gene activation of human huntingtin associated protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HAP1
• Locus ID: 9001
• Kit Components:

  GA105986G1, HAP1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105986G2, HAP1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105986G3, HAP1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001079870, NM_001079871, NM_003949, NM_177977, NM_001367459, NM_001367460, NM_001367461, NM_001367462
• Synonyms: HAP2; hHLP1; HIP5; HLP
• Summary: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]