Human SOCS3 activation kit by CRISPRa

CAT#: GA105994

SOCS3 CRISPRa kit - CRISPR gene activation of human suppressor of cytokine signaling 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SOCS3
• Locus ID: 9021
• Kit Components:

  GA105994G1, SOCS3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105994G2, SOCS3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105994G3, SOCS3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003955
• Synonyms: ATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3
• Summary: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]