Human PAPSS2 activation kit by CRISPRa

CAT#: GA106026

PAPSS2 CRISPRa kit - CRISPR gene activation of human 3'-phosphoadenosine 5'-phosphosulfate synthase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PAPSS2
• Locus ID: 9060
• Kit Components:

  GA106026G1, PAPSS2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106026G2, PAPSS2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106026G3, PAPSS2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001015880, NM_004670
• Synonyms: ATPSK2; BCYM4; SK2
• Summary: Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]