Human ASH2L activation kit by CRISPRa

CAT#: GA106033

ASH2L CRISPRa kit - CRISPR gene activation of human ASH2 like, histone lysine methyltransferase complex subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ASH2L
• Locus ID: 9070
• Kit Components:

  GA106033G1, ASH2L gRNA vector 1 in pCas-Guide-CRISPRa

  GA106033G2, ASH2L gRNA vector 2 in pCas-Guide-CRISPRa

  GA106033G3, ASH2L gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001105214, NM_001261832, NM_001282272, NM_004674, NR_049736
• Synonyms: ASH2; ASH2L1; ASH2L2; Bre2
• Summary: Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis. [UniProtKB/Swiss-Prot Function]