Human TID1 (DNAJA3) activation kit by CRISPRa

CAT#: GA106052

DNAJA3 CRISPRa kit - CRISPR gene activation of human DnaJ heat shock protein family (Hsp40) member A3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DNAJA3
• Locus ID: 9093
• Kit Components:

  GA106052G1, DNAJA3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106052G2, DNAJA3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106052G3, DNAJA3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001135110, NM_001286516, NM_005147
• Synonyms: HCA57; hTID-1; TID1
• Summary: This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]