Human USP8 activation kit by CRISPRa

CAT#: GA106060

USP8 CRISPRa kit - CRISPR gene activation of human ubiquitin specific peptidase 8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: USP8
• Locus ID: 9101
• Kit Components:

  GA106060G1, USP8 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106060G2, USP8 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106060G3, USP8 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001128610, NM_001128611, NM_001283049, NM_005154
• Synonyms: HumORF8; SPG59; UBPY
• Summary: This gene encodes a protein that belongs to the ubiquitin-specific processing protease family of proteins. The encoded protein is thought to regulate the morphology of the endosome by ubiquitination of proteins on this organelle and is involved in cargo sorting and membrane trafficking at the early endosome stage. This protein is required for the cell to enter the S phase of the cell cycle and also functions as a positive regulator in the Hedgehog signaling pathway in development. Pseudogenes of this gene are present on chromosomes 2 and 6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]