Human N myc interactor (NMI) activation kit by CRISPRa

CAT#: GA106066

NMI CRISPRa kit - CRISPR gene activation of human N-myc and STAT interactor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NMI
• Locus ID: 9111
• Kit Components:

  GA106066G1, NMI gRNA vector 1 in pCas-Guide-CRISPRa

  GA106066G2, NMI gRNA vector 2 in pCas-Guide-CRISPRa

  GA106066G3, NMI gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004688
• Synonyms: N-myc (and STAT) interactor; N-myc-interactor; N-myc and STAT interactor; N-myc interactor
• Summary: NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]