Human KCNQ4 activation kit by CRISPRa

CAT#: GA106085

KCNQ4 CRISPRa kit - CRISPR gene activation of human potassium voltage-gated channel subfamily Q member 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNQ4
• Locus ID: 9132
• Kit Components:

  GA106085G1, KCNQ4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106085G2, KCNQ4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106085G3, KCNQ4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004700, NM_172163
• Synonyms: DFNA2; DFNA2A; KV7.4
• Summary: The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]