Human DEDD activation kit by CRISPRa

CAT#: GA106128

DEDD CRISPRa kit - CRISPR gene activation of human death effector domain containing

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DEDD
• Locus ID: 9191
• Kit Components:

  GA106128G1, DEDD gRNA vector 1 in pCas-Guide-CRISPRa

  GA106128G2, DEDD gRNA vector 2 in pCas-Guide-CRISPRa

  GA106128G3, DEDD gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001039711, NM_001039712, NM_001330765, NM_004216, NM_032998
• Synonyms: CASP8IP1; DEDD1; DEFT; FLDED1; KE05
• Summary: This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]