Human PDLIM7 activation kit by CRISPRa

CAT#: GA106176

PDLIM7 CRISPRa kit - CRISPR gene activation of human PDZ and LIM domain 7

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PDLIM7
• Locus ID: 9260
• Kit Components:

  GA106176G1, PDLIM7 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106176G2, PDLIM7 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106176G3, PDLIM7 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005451, NM_203352, NM_203353, NM_213636, NR_103804
• Synonyms: LMP1; LMP3
• Summary: The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]