Human MAPKAP Kinase 2 (MAPKAPK2) activation kit by CRISPRa

CAT#: GA106177

MAPKAPK2 CRISPRa kit - CRISPR gene activation of human MAPK activated protein kinase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MAPKAPK2
• Locus ID: 9261
• Kit Components:

  GA106177G1, MAPKAPK2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106177G2, MAPKAPK2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106177G3, MAPKAPK2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004759, NM_032960
• Synonyms: MAPKAP-K2; MK-2; MK2
• Summary: This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]