Human Cytohesin 3 (CYTH3) activation kit by CRISPRa

CAT#: GA106180

CYTH3 CRISPRa kit - CRISPR gene activation of human cytohesin 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CYTH3
• Locus ID: 9265
• Kit Components:

  GA106180G1, CYTH3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106180G2, CYTH3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106180G3, CYTH3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004227, NM_001367580, NM_001367582, NM_001367581
• Synonyms: ARNO3; cytohesin-3; GRP1; PSCD3
• Summary: This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. [provided by RefSeq, Jul 2008]