Human Cytohesin 1 (CYTH1) activation kit by CRISPRa

CAT#: GA106182

CYTH1 CRISPRa kit - CRISPR gene activation of human cytohesin 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CYTH1
• Locus ID: 9267
• Kit Components:

  GA106182G1, CYTH1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106182G2, CYTH1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106182G3, CYTH1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001292018, NM_001292019, NM_004762, NM_017456, NM_001365038, NM_001365039, NM_001365040, NM_001365037, NM_001365041
• Synonyms: B2-1; CYTOHESIN-1; D17S811E; PSCD1; SEC7
• Summary: The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]