Human ITGB1BP1 activation kit by CRISPRa

CAT#: GA106183

ITGB1BP1 CRISPRa kit - CRISPR gene activation of human integrin subunit beta 1 binding protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ITGB1BP1
• Locus ID: 9270
• Kit Components:

  GA106183G1, ITGB1BP1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106183G2, ITGB1BP1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106183G3, ITGB1BP1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001319066, NM_001319067, NM_001319068, NM_001319069, NM_001319070, NM_004763, NM_022334, NR_134951, NR_134952, NR_134953, NR_134954, NR_134955, NR_134956, NR_134957, NM_001369744, NM_001369746, NM_001369747, NM_001369749, NM_001369745, NM_001369748, NM_001369750
• Synonyms: ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1; ICAP1A; ICAP1B
• Summary: The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]