Human ASIC3 activation kit by CRISPRa

CAT#: GA106203

ASIC3 CRISPRa kit - CRISPR gene activation of human acid sensing ion channel subunit 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ASIC3
• Locus ID: 9311
• Kit Components:

  GA106203G1, ASIC3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106203G2, ASIC3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106203G3, ASIC3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004769, NM_020321, NM_020322, NR_046401
• Synonyms: ACCN3; DRASIC; SLNAC1; TNaC1
• Summary: This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]