Human HMGN3 activation kit by CRISPRa

CAT#: GA106214

HMGN3 CRISPRa kit - CRISPR gene activation of human high mobility group nucleosomal binding domain 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HMGN3
• Locus ID: 9324
• Kit Components:

  GA106214G1, HMGN3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106214G2, HMGN3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106214G3, HMGN3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001201362, NM_001201363, NM_001318884, NM_001318885, NM_001318886, NM_001318887, NM_001318888, NM_004242, NM_138730
• Synonyms: PNAS-24; PNAS-25; TRIP7
• Summary: The protein encoded by this gene binds thyroid hormone receptor beta in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is a related pseudogene on chromosome 1. [provided by RefSeq, Jan 2016]