Human ASC1 (TRIP4) activation kit by CRISPRa

CAT#: GA106215

TRIP4 CRISPRa kit - CRISPR gene activation of human thyroid hormone receptor interactor 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TRIP4
• Locus ID: 9325
• Kit Components:

  GA106215G1, TRIP4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106215G2, TRIP4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106215G3, TRIP4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001321924, NM_016213, NR_135855
• Synonyms: ASC-1; ASC1; HsT17391; MDCDC; SMABF1; ZC2HC5
• Summary: This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). [provided by RefSeq, Apr 2016]