Human GTF3C4 activation kit by CRISPRa

CAT#: GA106218

GTF3C4 CRISPRa kit - CRISPR gene activation of human general transcription factor IIIC subunit 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GTF3C4
• Locus ID: 9329
• Kit Components:

  GA106218G1, GTF3C4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106218G2, GTF3C4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106218G3, GTF3C4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_012204, NR_133925
• Synonyms: KAT12; TF3C-delta; TFIII90; TFIIIC90; TFIIIC290; TFIIICDELTA
• Summary: Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box. [UniProtKB/Swiss-Prot Function]