Human CD163 activation kit by CRISPRa

CAT#: GA106221

CD163 CRISPRa kit - CRISPR gene activation of human CD163 molecule

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CD163
• Locus ID: 9332
• Kit Components:

  GA106221G1, CD163 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106221G2, CD163 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106221G3, CD163 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004244, NM_203416, NM_001370146, NR_163255, NM_001370145
• Synonyms: M130; MM130; SCARI1
• Summary: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]