Human EBP50 (SLC9A3R1) activation kit by CRISPRa

CAT#: GA106248

SLC9A3R1 CRISPRa kit - CRISPR gene activation of human SLC9A3 regulator 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SLC9A3R1
• Locus ID: 9368
• Kit Components:

  GA106248G1, SLC9A3R1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106248G2, SLC9A3R1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106248G3, SLC9A3R1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004252
• Synonyms: EBP50; NHERF; NHERF-1; NHERF1; NPHLOP2
• Summary: This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer. [provided by RefSeq, Sep 2009]