Human NRXN3 activation kit by CRISPRa

CAT#: GA106249

NRXN3 CRISPRa kit - CRISPR gene activation of human neurexin 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NRXN3
• Locus ID: 9369
• Kit Components:

  GA106249G1, NRXN3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106249G2, NRXN3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106249G3, NRXN3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001105250, NM_001272020, NM_004796, NM_138970, NR_073546, NR_073547, NM_001330195, NM_001366425, NM_001366426, NR_158975, NR_158973, NR_158974
• Synonyms: C14orf60
• Summary: This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]