Human Neurexin II alpha (NRXN2) activation kit by CRISPRa

CAT#: GA106259

NRXN2 CRISPRa kit - CRISPR gene activation of human neurexin 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NRXN2
• Locus ID: 9379
• Kit Components:

  GA106259G1, NRXN2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106259G2, NRXN2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106259G3, NRXN2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_015080, NM_138732, NM_138734
• Synonyms: FLJ40892; KIAA0921
• Summary: This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992). [provided by RefSeq, Jun 2010]