Human Leupaxin (LPXN) activation kit by CRISPRa

CAT#: GA106276

LPXN CRISPRa kit - CRISPR gene activation of human leupaxin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LPXN
• Locus ID: 9404
• Kit Components:

  GA106276G1, LPXN gRNA vector 1 in pCas-Guide-CRISPRa

  GA106276G2, LPXN gRNA vector 2 in pCas-Guide-CRISPRa

  GA106276G3, LPXN gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001143995, NM_001307951, NM_004811
• Synonyms: LDPL
• Summary: The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2009]