Human TJP2 activation kit by CRISPRa

CAT#: GA106284

TJP2 CRISPRa kit - CRISPR gene activation of human tight junction protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TJP2
• Locus ID: 9414
• Kit Components:

  GA106284G1, TJP2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106284G2, TJP2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106284G3, TJP2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001170414, NM_001170415, NM_001170416, NM_001170630, NM_004817, NM_201629, NM_001369873, NM_001369875, NM_001369870, NM_001369871, NM_001369872, NM_001369874
• Synonyms: C9DUPq21.11; DFNA51; DUP9q21.11; PFIC4; X104; ZO2
• Summary: This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]