Human PERK (EIF2AK3) activation kit by CRISPRa

CAT#: GA106311

EIF2AK3 CRISPRa kit - CRISPR gene activation of human eukaryotic translation initiation factor 2 alpha kinase 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EIF2AK3
• Locus ID: 9451
• Kit Components:

  GA106311G1, EIF2AK3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106311G2, EIF2AK3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106311G3, EIF2AK3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001313915, NM_004836
• Synonyms: PEK; PERK; WRS
• Summary: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]