Human TCCR (IL27RA) activation kit by CRISPRa

CAT#: GA106323

IL27RA CRISPRa kit - CRISPR gene activation of human interleukin 27 receptor subunit alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IL27RA
• Locus ID: 9466
• Kit Components:

  GA106323G1, IL27RA gRNA vector 1 in pCas-Guide-CRISPRa

  GA106323G2, IL27RA gRNA vector 2 in pCas-Guide-CRISPRa

  GA106323G3, IL27RA gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004843
• Synonyms: CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1
• Summary: In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008]