Human EIF4EL3 (EIF4E2) activation kit by CRISPRa
CAT#: GA106327
EIF4E2 CRISPRa kit - CRISPR gene activation of human eukaryotic translation initiation factor 4E family member 2
Find the corresponding CRISPRi Inhibitor Kit
USD 1,290.00
2 Weeks*
Specifications
Product Data | |
Format | 3gRNAs, 1 scramble ctrl and 1 enhancer vector |
Symbol | EIF4E2 |
Locus ID | 9470 |
Kit Components | GA106327G1, EIF4E2 gRNA vector 1 in pCas-Guide-CRISPRa GA106327G2, EIF4E2 gRNA vector 2 in pCas-Guide-CRISPRa GA106327G3, EIF4E2 gRNA vector 3 in pCas-Guide-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100058 |
Disclaimer | The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001276336, NM_001276337, NM_001282958, NM_001330201, NM_001330202, NM_001330203, NM_004846 |
Synonyms | 4E-LP; 4EHP; EIF4EL3; IF4e |
Summary | Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap. [UniProtKB/Swiss-Prot Function] |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN401391 | EIF4E2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,290.00 |
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