Human Myotilin (MYOT) activation kit by CRISPRa

CAT#: GA106349

MYOT CRISPRa kit - CRISPR gene activation of human myotilin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MYOT
• Locus ID: 9499
• Kit Components:

  GA106349G1, MYOT gRNA vector 1 in pCas-Guide-CRISPRa

  GA106349G2, MYOT gRNA vector 2 in pCas-Guide-CRISPRa

  GA106349G3, MYOT gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001135940, NM_001300911, NM_006790
• Synonyms: LGMD1; LGMD1A; MFM3; TTID; TTOD
• Summary: This gene encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2008]