Human ADAMTS1 activation kit by CRISPRa

CAT#: GA106357

ADAMTS1 CRISPRa kit - CRISPR gene activation of human ADAM metallopeptidase with thrombospondin type 1 motif 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ADAMTS1
• Locus ID: 9510
• Kit Components:

  GA106357G1, ADAMTS1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106357G2, ADAMTS1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106357G3, ADAMTS1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006988
• Synonyms: C3-C5; METH1
• Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]