Human EEF1E1 activation kit by CRISPRa

CAT#: GA106367

EEF1E1 CRISPRa kit - CRISPR gene activation of human eukaryotic translation elongation factor 1 epsilon 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EEF1E1
• Locus ID: 9521
• Kit Components:

  GA106367G1, EEF1E1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106367G2, EEF1E1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106367G3, EEF1E1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001135650, NM_004280
• Synonyms: AIMP3; P18
• Summary: This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]