Human BCAR1 activation kit by CRISPRa

CAT#: GA106403

BCAR1 CRISPRa kit - CRISPR gene activation of human BCAR1 scaffold protein, Cas family member

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BCAR1
• Locus ID: 9564
• Kit Components:

  GA106403G1, BCAR1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106403G2, BCAR1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106403G3, BCAR1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001170714, NM_001170715, NM_001170716, NM_001170717, NM_001170718, NM_001170719, NM_001170720, NM_001170721, NM_014567
• Synonyms: CAS; CAS1; CASS1; CRKAS; P130Cas
• Summary: The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017]