Human ERp72 (PDIA4) activation kit by CRISPRa

CAT#: GA106428

PDIA4 CRISPRa kit - CRISPR gene activation of human protein disulfide isomerase family A member 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PDIA4
• Locus ID: 9601
• Kit Components:

  GA106428G1, PDIA4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106428G2, PDIA4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106428G3, PDIA4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004911
• Synonyms: ERp-72; ERP70; ERP72
• Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. This protein, when bound to cyclophilin B, enhances the rate of immunoglobulin G intermolecular disulfide bonding and antibody assembly. [provided by RefSeq, Dec 2016]