Human IKBKE activation kit by CRISPRa

CAT#: GA106459

IKBKE CRISPRa kit - CRISPR gene activation of human inhibitor of nuclear factor kappa B kinase subunit epsilon

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IKBKE
• Locus ID: 9641
• Kit Components:

  GA106459G1, IKBKE gRNA vector 1 in pCas-Guide-CRISPRa

  GA106459G2, IKBKE gRNA vector 2 in pCas-Guide-CRISPRa

  GA106459G3, IKBKE gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001193321, NM_001193322, NM_014002
• Synonyms: IKK-E; IKK-i; IKKE; IKKI
• Summary: IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]). [supplied by OMIM, Oct 2009]