Human FISH (SH3PXD2A) activation kit by CRISPRa

CAT#: GA106461

SH3PXD2A CRISPRa kit - CRISPR gene activation of human SH3 and PX domains 2A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SH3PXD2A
• Locus ID: 9644
• Kit Components:

  GA106461G1, SH3PXD2A gRNA vector 1 in pCas-Guide-CRISPRa

  GA106461G2, SH3PXD2A gRNA vector 2 in pCas-Guide-CRISPRa

  GA106461G3, SH3PXD2A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014631, NM_001365079
• Synonyms: FISH; SH3MD1; TKS5
• Summary: Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. [UniProtKB/Swiss-Prot Function]