Human RIM2 (RIMS2) activation kit by CRISPRa

CAT#: GA106510

RIMS2 CRISPRa kit - CRISPR gene activation of human regulating synaptic membrane exocytosis 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RIMS2
• Locus ID: 9699
• Kit Components:

  GA106510G1, RIMS2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106510G2, RIMS2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106510G3, RIMS2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001100117, NM_001282881, NM_001282882, NM_014677, NM_001348484, NM_001348485, NM_001348486, NM_001348487, NM_001348488, NM_001348489, NM_001348490, NM_001348491, NM_001348492, NM_001348493, NM_001348494, NM_001348495, NM_001348496, NM_001348497, NM_001348498, NM_001348499, NM_001348500, NM_001348501, NM_001348502, NM_001348503, NM_001348504, NM_001348505, NM_001348506, NM_001348507, NM_001348508, NM_001348509, NR_145710, NR_145711
• Synonyms: OBOE; RAB3IP3; RIM2
• Summary: The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017]