Human CAPON (NOS1AP) activation kit by CRISPRa

CAT#: GA106530

NOS1AP CRISPRa kit - CRISPR gene activation of human nitric oxide synthase 1 adaptor protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NOS1AP
• Locus ID: 9722
• Kit Components:

  GA106530G1, NOS1AP gRNA vector 1 in pCas-Guide-CRISPRa

  GA106530G2, NOS1AP gRNA vector 2 in pCas-Guide-CRISPRa

  GA106530G3, NOS1AP gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001126060, NM_001164757, NM_014697
• Synonyms: 6330408P19Rik; CAPON
• Summary: This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]