Human KMT2B activation kit by CRISPRa

CAT#: GA106563

KMT2B CRISPRa kit - CRISPR gene activation of human lysine methyltransferase 2B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KMT2B
• Locus ID: 9757
• Kit Components:

  GA106563G1, KMT2B gRNA vector 1 in pCas-Guide-CRISPRa

  GA106563G2, KMT2B gRNA vector 2 in pCas-Guide-CRISPRa

  GA106563G3, KMT2B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014727
• Synonyms: CXXC10; HRX2; MLL1B; MLL2; MLL4; TRX2; WBP-7; WBP7
• Summary: This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq, Jul 2008]