Human RNF40 activation kit by CRISPRa

CAT#: GA106607

RNF40 CRISPRa kit - CRISPR gene activation of human ring finger protein 40

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RNF40
• Locus ID: 9810
• Kit Components:

  GA106607G1, RNF40 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106607G2, RNF40 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106607G3, RNF40 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001207033, NM_001207034, NM_001286572, NM_014771, NM_194352
• Synonyms: BRE1B; RBP95; STARING
• Summary: The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]