Human MVP activation kit by CRISPRa

CAT#: GA106740

MVP CRISPRa kit - CRISPR gene activation of human major vault protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MVP
• Locus ID: 9961
• Kit Components:

  GA106740G1, MVP gRNA vector 1 in pCas-Guide-CRISPRa

  GA106740G2, MVP gRNA vector 2 in pCas-Guide-CRISPRa

  GA106740G3, MVP gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001293204, NM_001293205, NM_005115, NM_017458
• Synonyms: LRP; VAULT1
• Summary: This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]