Human MED13 activation kit by CRISPRa

CAT#: GA106747

MED13 CRISPRa kit - CRISPR gene activation of human mediator complex subunit 13

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MED13
• Locus ID: 9969
• Kit Components:

  GA106747G1, MED13 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106747G2, MED13 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106747G3, MED13 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005121
• Synonyms: ARC250; DRIP250; HSPC221; THRAP1; TRAP240
• Summary: This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq, Jul 2008]