Human KCNE2 activation kit by CRISPRa

CAT#: GA106765

KCNE2 CRISPRa kit - CRISPR gene activation of human potassium voltage-gated channel subfamily E regulatory subunit 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNE2
• Locus ID: 9992
• Kit Components:

  GA106765G1, KCNE2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106765G2, KCNE2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106765G3, KCNE2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_172201
• Synonyms: ATFB4; LQT5; LQT6; MIRP1
• Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]