Human SRA1 activation kit by CRISPRa

CAT#: GA106780

SRA1 CRISPRa kit - CRISPR gene activation of human steroid receptor RNA activator 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SRA1
• Locus ID: 10011
• Kit Components:

  GA106780G1, SRA1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106780G2, SRA1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106780G3, SRA1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001035235, NM_001253764, NR_045586, NR_045587
• Synonyms: pp7684; SRA; SRAP; STRAA1
• Summary: Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]