Human LNK (SH2B3) activation kit by CRISPRa

CAT#: GA106787

SH2B3 CRISPRa kit - CRISPR gene activation of human SH2B adaptor protein 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SH2B3
• Locus ID: 10019
• Kit Components:

  GA106787G1, SH2B3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106787G2, SH2B3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106787G3, SH2B3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001291424, NM_005475
• Synonyms: IDDM20; LNK
• Summary: This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]