Human GLCNE (GNE) activation kit by CRISPRa

CAT#: GA106788

GNE CRISPRa kit - CRISPR gene activation of human glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GNE
• Locus ID: 10020
• Kit Components:

  GA106788G1, GNE gRNA vector 1 in pCas-Guide-CRISPRa

  GA106788G2, GNE gRNA vector 2 in pCas-Guide-CRISPRa

  GA106788G3, GNE gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001128227, NM_001190383, NM_001190384, NM_001190388, NM_005476
• Synonyms: DMRV; GLCNE; IBM2; NM; Uae1
• Summary: The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]