Human HCN4 activation kit by CRISPRa

CAT#: GA106789

HCN4 CRISPRa kit - CRISPR gene activation of human hyperpolarization activated cyclic nucleotide gated potassium channel 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HCN4
• Locus ID: 10021
• Kit Components:

  GA106789G1, HCN4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106789G2, HCN4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106789G3, HCN4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005477
• Synonyms: SSS2
• Summary: This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]