Human SAE1 activation kit by CRISPRa

CAT#: GA106812

SAE1 CRISPRa kit - CRISPR gene activation of human SUMO1 activating enzyme subunit 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SAE1
• Locus ID: 10055
• Kit Components:

  GA106812G1, SAE1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106812G2, SAE1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106812G3, SAE1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145713, NM_001145714, NM_005500, NM_016402, NR_027280
• Synonyms: AOS1; HSPC140; SUA1; UBLE1A
• Summary: Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]). [supplied by OMIM, Mar 2010]