Human PHEMX (TSPAN32) activation kit by CRISPRa

CAT#: GA106830

TSPAN32 CRISPRa kit - CRISPR gene activation of human tetraspanin 32

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TSPAN32
• Locus ID: 10077
• Kit Components:

  GA106830G1, TSPAN32 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106830G2, TSPAN32 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106830G3, TSPAN32 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005705, NM_139022, NM_139024
• Synonyms: MGC22455; PHEMX; PHMX; TSSC6
• Summary: This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]