Human RASGRP1 activation kit by CRISPRa

CAT#: GA106869

RASGRP1 CRISPRa kit - CRISPR gene activation of human RAS guanyl releasing protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RASGRP1
• Locus ID: 10125
• Kit Components:

  GA106869G1, RASGRP1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106869G2, RASGRP1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106869G3, RASGRP1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001128602, NM_001306086, NM_005739
• Synonyms: CALDAG-GEFI; CALDAG-GEFII; hRasGRP1; RASGRP; V
• Summary: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]